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Johns Hopkins Center for Psychedelic and Consciousness Research The fact that these new and positive clinical findings had to be postponed for several decades dramatically illustrates the destructive capacity of politics to hinder potentially significant medical advances. Romano et al. examined the effect of serotonin depletion on eyeblink conditioning by bilateral intracerebroventricular administration of 5,7-dihydroxytryptamine. They achieved up to 85% and 90% depletion of serotonin in the cortex and hippocampus, respectively. Serotonin depletion failed to change the expression of 5-HT2A receptors, however, and had no significant effect on acquisition of trace classic conditioning. Serotonin depletion likewise had no effect on the enhancement of learning produced by LSD or on the retardation of learning produced by MDL11939. Overall, at least in rodent models, Psychedelics seem to exacerbate neophobia, increase responsiveness to sensory stimulation, and interfere with response hab